Magnetically Triggered Dual Functional Nanoparticles for Resistance-Free Apoptotic Hyperthermia
Recently, innovative therapeutic approaches beyond conventional orthodox therapies, such as chemical drugs, have been actively developed and one of them is cancer hyperthermia, in which thermal treatments of cancer cells at mild temperature (40–45 8C) preferentially eliminate them through an apoptotic cell death process without damaging normal tissues. Despite all these potential advantages, however, hyperthermia for apoptosis, in general, is ineffective because heat-treated cells readily acquire resistance to thermal stress and markedly increase their survival rate, which is called thermoresistance. In this study, we introduce a new type of resistance-free apoptosis-inducing magnetic nanoparticle (RAIN) that can promote thermoresistance-free apoptosis.
Angew. Chem. Int. Ed.2013, 52(49), pp13047-13051 Dec. 2, 2013